Objective To discuss the effective and safety of MPA1 catheter in aiding and tracing the guiding catheter passage during radial artery spasm induced by transradial coronary intervention (TRI). Methods The patients (n=44) with coronary heart disease (CHD) diagnosed by transradial echocardiography and suffered from radial artery spasm during TRI were chosen from Department of Cardiology in the Seventh Medical Center of PLA General Hospital from Feb. 2021 to Dec. 2021, and divided randomly into medication group and catheter-assisted group (each n=22). The routine antispasmodic drugs was used in medication group, and MPA1 catheter was used in catheter-assisted group for aiding and tracing the guiding catheter to pass through spasmodic radial artery. The success rate and time of guiding catheter passing through spasmodic radial artery, and complications related to radial artery damage were compared between 2 groups after the operation and in follow-up period. Results The guiding catheter all passed through smoothly the spasmodic radial artery in 22 cases and success rate was 100% in catheter-assisted group, and guiding catheter passed smoothly through the spasmodic radial artery only in 15 cases and success rate was 68.18% in medication group. The comparison between 2 groups showed that the time of guiding catheter passage was significantly shorter, and complications related to radial artery damage after the operation and in follow-up period were less in catheter-assisted than those in medication group (P<0.05). Conclusion MPA1 catheter is safe and effective with higher success rate and short operative time in aiding and tracing the guiding catheter passing through spasmodic radial artery.