Objective To investigate the changes of urea albumin creatinine ratio (UACR) in patients with chronic heart failure (CHF). Methods CHF patients were chosen into observation group (n=140) and healthy controls were chosen into control group (n=70) from Department of Cardiology in Chinese PLA General Hospital from Jan. 2020 to June 2021. According to New York Heart Association classification of heart function (NYHA), the observation group was divided into NYHA grade I subgroup (n=12), NYHA grade II subgroup (n=39), NYHA grade III subgroup (n=43) and NYHA grade IV subgroup (n=46). The levels of serum creatinine (SCr), urinary micro albuminuria (UMA), UACR, N-terminal pro-brain natriuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF), left ventricular end-diastolic inner diameter (LVEDd) and left ventricular fraction shortening (LVFS) were compared among all groups, and UACR was analyzed and compared among all subgroups. Results The levels of UMA, UACR, SCr and NT-proBNP were significantly higher in observation group than those in control group, and in observation group, the higher the NYHA grade, the more significant the increases of UMA, UACR, SCr and NT-proBNP. The levels of LVEF and LVFS were significantly lower in observation group than those in control group, and in observation group, the higher the NYHA grade, the more significant the decreases of LVEF and LVFS. The level of LEVDd was significantly higher in observation group than that in control group, and in observation group, the higher the NYHA grade, the more significant the increases of LEVDd (P<0.05). The comparison in UACR level among all subgroups showed that the difference had statistical significance (P<0.05). Conclusion The detections of UMA and UACR are easy and cheap, which has some reference value to assessing disease severity in CHF patients, and is worth clinical promoting.
