目的 分析职业性心理应激对心血管疾病的影响。方法 以2020年3月至2021年7月于泰州市人民医院心内科及体检门诊健康体检的580例在职期间人员作为研究对象，均予以OSI-R量表职业心理应激水平的问卷调查，按是否存在职业性心理应激分为病例组（n=290）和对照组（n=290），检测常规生化指标。多因素Logistic回归分析其与心血管疾病的影响。结果 共纳入研究对象580例，其中病例组的职业任务问卷总分及其6个维度，个体紧张反应问卷总分及其5个维度的评分均高于对照组，病例组应变个体能力问卷总分及其5个维度评分均低于对照组，差异有统计学意义（P＜0.05）。对照组的收缩压（SBP）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、同型半胱氨酸（Hcy）及体质指数（BMI）均低于病例组；对照组高密度脂蛋白胆固醇（HDL-C）高于病例组，差异有统计学意义（P＜0.05）。不同职业任务问卷评分间SBP、HDL-C、LDL-C及BMI差异均有统计学意义（P＜0.05）；不同个体紧张反应问卷评分间TG及BMI差异均有统计学意义（P＜0.05）；不同应变个体能力问卷评分间SBP、TG、HDL-C及BMI差异均有统计学意义（P＜0.05）。SBP、BMI、职业应激因素水平及个体紧张反应水平均是心血管疾病的危险因素，HDL-C及应变个体能力水平是心血管疾病的保护因素。结论 职业性心理应激与心血管系统疾病联系密切，多种因素可对其产生影响。

Objective To study Study on the Relationship between Occupational Psychological Stress and Cardiovascular Diseases. Methods 580 healthy people who had physical examination in the Department of Cardiology and physical examination clinic of Taizhou People's Hospital were selected as the research objects. All of them were investigated by OSI-R questionnaire. They were divided into case group and control group according to the existence of occupational psychological stress. Multivariate Logistic regression analysis was used to explore the relationship between CVD and CVD. Results 580 cases with into the object of study, in which case group (n=290) the professional task of their scores and six dimensions, individual stress reaction questionnaire scores and the five dimensions of score were higher than the control group (n=290), and individual ability questionnaire score cases strain five dimension scores are lower than the control group, difference has statistical significance (P＜0.05). The systolic blood pressure (SBP), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), homocysteine (Hcy) and body mass index (BMI) in the control group were lower than those in the case group. The HDL-C index of the control group was higher than that of the case group, and the difference was statistically significant (P ＜0.05). There were significant differences in SBP, HDL-C, LDL-C and BMI among different occupational task questionnaire scores (P＜0.05). There were significant differences in TG and BMI among different individual stress response questionnaire scores (P＜0.05). There were significant differences in SBP, TG, HDL-C and BMI among different strain individual ability questionnaire scores (P＜0.05). SBP, BMI, occupational stress factor level and individual stress response level are risk factors of cardiovascular disease, HDL-C and strain individual ability level are protective factors of cardiovascular disease. Conclusion Occupational psychological stress is closely related to cardiovascular diseases, which can be affected by many factors.