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硝苯地平控释片联合厄贝沙坦片治疗原发性高血压疗效分析

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目的 对硝苯地平控释片联合厄贝沙坦片治疗原发性高血压患者的疗效分析。方法 选取
2016年1月至2018年1月间于青海省交通医院心血管内科收治的原发性高血压患者186例,随机分为实验
组和对照组两组,每组各93例。对照组采取硝苯地平控释片联合酒石酸美托洛尔片治疗,实验组为硝
苯地平控释片联合厄贝沙坦片治疗;比较两组患者的临床疗效、血压情况及生活质量评分。结果 实验
组总有效率为97.85%,对照组为86.02%,差异有统计学意义(P<0.01)。对患者血压监测,实验组患
者血压控制情况包括24 h收缩压(125.84±4.26)mmHg、24 h舒张压(80.82±3.24)mmHg明显优于对
照组,差异有统计学意义(P<0.01)。实验组生活质量评分包括躯体功能(47.83±14.35)、社会功
能(56.53±13.06)、情感功能(60.76±15.62)、心理功能(57.04±15.27)显著高于对照组,两组比
较,差异有统计学意义(P<0.05)。结论 对于原发性高血压患者的治疗,采取硝苯地平控释片联合厄
贝沙坦片,临床疗效较好,对改善患者血压水平的效果满意。

Abstract:

 Objective To analyze the curative effect of nifedipine controlled release tablets combined with
irbesartan tablets on essential hypertension (EH). Methods EH patients (n=186) were chosen from Department of
Cardiovascular Medicine in Jiaotong Hospital of Qinghai Province from Jan. 2016 to Jan. 2018, and then divided
randomly into test group and control group (each n=93). The control group was treated with nifedipine controlled
release tablets combined with metoprolol tartrate tablets, and test group was treated with nifedipine controlled
release tablets combined with irbesartan tablets. The clinical efficacy, blood pressure and scores of quality of life
(QOL) were compared between 2 groups. Results The total effective rate was 97.85% in test group and 86.02% in
control group (P<0.01). The blood pressure controlling was superior in test group to that in control group, including
24-h systolic blood pressure (125.84±4.26) mmHg and diastolic blood pressure (80.82±3.24) mmHg (P<0.01).
The scores of QOL were significantly higher in test group than those in control group (P<0.05), including body
function (47.83±14.35), social function (56.53±13.06), emotional function (60.76±15.62) and psychological
function (57.04±15.27). Conclusion Nifedipine controlled release tablets combined with irbesartan tablets has
higher curative effect in EH treatment with ideal efficacy of improving blood pressure level.

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参考文献:

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