再次住院及主要不良心脏事件（MACE）的发生，以及复查造影结果。结果 将24 h按每2 h划分，在
vs. 50.3%，P=0.041），更高的因心衰再次住院的累计风险（53.5% vs. 39.3%，P=0.032）。多因素COX
管血运重建（NON-TVR）发生率（29.3% vs. 11.1%，P=0.019）。结论 06:00~11:59期间发生AMI患者出
Objective To discuss the circadian variation of acute myocardial infarction (AMI) in Chinese
population and relationship between it and patients’ prognosis within 12 months. Methods AMI patients (n=467)
with definite diagnosis and AMI attack time were chosen from Department of Cardiology in China-Japan Union
Hospital of Jilin University from Jan. 1, 2015 to Oct. 25, 2016 and their data was retrospectively analyzed. All patients
were divided into morning group (AMI attacked from 06:00 am to 11:59 am, n=162) and other time group (n=305). The
clinical basic materials, incidence of death or heart failure during hospitalization period, and all-cause mortality, reonset
acute coronary syndrome (ACS), re-hospitalization due to heart failure and major adverse cardiovascular events
(MACE) during follow-up period after discharged were recorded, and results of coronary angiography were reexamined.
Results One peak of AMI attack was found from 06:00 am to 07:59 am (13.27%) based on dividing 24 h into 2 h.
One peak of AMI attack was found from 06:00 am to 11:59 am (34.69%) based on dividing 24 h into 6 h. The results
of Kaplan-Meier survival curve analysis showed that the aggregation risks of MACE (76.3% vs. 50.3%, P=0.041) and
re-hospitalization due to heart failure (53.5% vs. 39.3%, P=0.032) were higher in morning group within 12 months
after discharged. The results of multi-factor COX regression analysis showed that AMI attacked from 06:00 am to
11:59 am was an independent risk factor of AMI (HR=6.458, 95%CI: 2.015~20.697, P=0.002) within 12 months after
discharged. The results of reexamination of coronary angiography showed that the incidence rate of non-target vessel
revascularization (NON-TVR) was higher in morning group (29.3% vs. 11.1%, P=0.019) during follow-up period.
Conclusion The patients with AMI attack from 06:00 am to 11:59 am had higher aggregation rates of MACE and rehospitalization
due to heart failure and higher incidence rate of NON-TVR within 12 months after discharged. So more
attention should be paid to them, follow-up should be enhanced and MACE should be disposed in time.
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