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女性急性心肌梗死患者单核细胞与淋巴细胞比值和短期内发生主要心血管不良事件相关性研究

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目的 探讨女性急性心肌梗死(AMI)患者单核细胞与淋巴细胞比值(MLR)对于其首次
住院期间出现的主要不良心血管事件(MACEs)的预测价值。方法 纳入2013年1月1日至2017年12月31
日于中国武警特色医学中心就诊的女性AMI患者280例,根据住院期间是否发生MACEs将患者分为MACEs
组(n=50)及非MACEs组(n=230),分析两组患者的一般资料、病史信息、辅助检查、住院用药等,
采用ROC曲线分析MLR对住院期间MACEs发生的预测价值。结果 与非MACEs组相比,MACEs组年龄偏
高,有冠心病病史,检查资料显示MLR、肌酐、尿酸、D-二聚体较高,住院期间利尿剂、强心剂使用率
高,但ARB类降压药使用率低,差异有统计学意义。Logistic回归分析显示MLR是AMI发生后首次住院期
间MACEs发生的独立危险因素(P<0.05),在校正传统危险因素以后,MLR作为MACEs发生危险因素
的风险比有所下降 。ROC曲线显示MLR对于女性患者在AMI发生后的首次住院期间是否出现MACEs事件
具有预测价值。结论 MLR对女性AMI患者短期内出现MACEs具有预测价值。

Abstract:

Objective To investigate the prediction of major adverse cardiovascular events (MACEs) during
the first hospitalization of monocyte to lymphocyte ratio (MLR) in female patients with acute myocardial infraction
(AMI). value. Methods A total of 280 female patients with AMI were enrolled in the Chinese Armed Police
Special Medical Center from January 1, 2013 to December 31, 2017. According to the occurrence of MACEs during
hospitalization, the patients were divided into MACEs group (n=50) and non-MACEs group (n=230). The general
information, medical history information, auxiliary examinations and in-hospital medication of the two groups were
analyzed. The ROC curve was used to analyze the predictive value of MLR for the occurrence of MACEs during
hospitalization. Results Compared with non-MACEs group, MACEs group had a history of coronary artery disease.
Examination data showed that MLR, creatinine, uric acid and D-dimer were higher, diuretics and cardiotonic agents
were used more frequently during hospitalization, but ARB antihypertensive drugs were used less, the difference was
statistically significant. Logistic regression analysis showed that MLR was an independent risk factor for MACEs
during the first hospitalization after AMI (P<0.05). After adjusting for traditional risk factors, the risk ratio of MLR
as a risk factor for MACEs decreased. The ROC curve showed that MLR had predictive value for the occurrence of
MACEs in female patients during their first hospitalization after AMI. Conclusion MLR has predictive value for the
short-term occurrence of MACEs in female patients with AMI.

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